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Me (such as the Ssa1-4 proteins in yeast) come into action (Figure 1). They prevent aggregation by shielding hydrophobic segments, until they can release fast-folding molecules. In addition to assisting posttranslational folding, these chaperones participate in various other functions such as assisting proteolytic degradation of aggregated proteins and protein trafficking. Hsp70 chaperones can del

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