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Rgan protection (Masini et al., 1997; Alexiou et al., 2010, 2013; Collino et al., 2013). In rat lung, relaxin evokes an early and moderate increase in iNOS dependent on ERK1/2 activation that is counterbalanced by PI3K recruitment (Alexiou et al., 2013). In rat kidney (Collino et al., 2013), the peptide upregulates iNOS and activates eNOS via PI3K. It remains to be investigated whether over the lo

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