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Ewly synthesized cytosolicproteins interact with TRiC. It has been suggested that TRiC can assist cotranslational folding of individual domains of larger proteins because it can interact with nascent chains [10, 11]. Hsp90 is a one more chaperone system that can function downstream of the Hsp70s. It cooperates with a multitude of regulators and co-chaperones, and hence is a rather complex system (

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