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Ibrotic effects of relaxin. Relaxin-mediated increases in MMP-9 expression were also blocked by transfection of a dominant negative form of Akt or by small interfering RNA knockdown of ERK1/2, PKCz, Elk-1, c-fos, and, to a lesser extent, NFkB (Ahmad et al., 2012). This important study connects many of the known pathways of relaxin/ RXFP1 signaling to a well recognized physiologic response to relax

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