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Onation, and therefore relaxin deficient, exhibited a decreased glomerular filtration rate compared with that observed in normal pregnancies (Smith et al., 2006b). In a small study in human volunteers (Smith et al., 2006a), relaxin administered for 5 hours increased renal plasma flow by ;75 and fractional sodium excretion by ;25 but did not affect glomerular filtration rate (Smith et al., 2006a)

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