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Nd the positive inotropic effects occur in left atria (Kakouris et al., 1992; Ward et al., 1992; Wade et al., 1994; Tan et al., 1998; Mathieu et al., 2001). Chronotropic effects of relaxin are accompanied by the secretion of atrial natriuretic peptide in isolated perfused rat hearts (Toth et al., 1996). In rabbit sinoatrial node cells, relaxin increases the rate of spontaneous action potentials an

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