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To theprimary mechanism of action. Alternatively, these results may reflect MMP-2- or MMP-9-mediated release of extracellular matrix-bound VEGF (and PGF) (Bergers et al., 2000; van Hinsbergh et al., 2006) that could underpin the MMP-ETB pathway by stimulating expression of prepro-ET-1. Finally, relaxin promotes angiogenesis (Unemori et al., 1999; Unemori et al., 2000) by inducing VEGF and basic fi

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