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Ere the first biologic effects to be recorded (Hisaw, 1926), and a number of studies have examined this property as a possible treatment of the connective tissue disease scleroderma. Relaxin was safe and well tolerated in clinical trials and effective in some patients in a phase II trial (Seibold et al., 2000) but failed to show clinical efficacy in a larger scale phase III trial (Erikson andUnemo

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