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P60/Tric/CCTNative foldFigure 1: Role of the molecular chaperones in protein folding, removal from aggregates, and delivery to the proteasome. Newly synthesized proteins start to fold cotranslationally, and they are assisted by ribosome-associated chaperones. Not all proteins reach their native state after synthesis, and they are assisted by ATP-dependent chaperones of the Hsp70 family. They will

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