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Y during its synthesis (figure adapted from [16]).recognized by the 26S proteasome. Ubiquitination of proteins occurs in several steps and is catalyzed by 3 classes of enzymes called ubiquitin-activating enzyme (E1), ubiquitinconjugating enzymes (E2s, represented by a small group of proteins), and finally ubiquitin-ligating enzymes (E3s), which determine the substrate specificity and which are ver

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