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Mbrane model (McDonald et al., 2003) and in spontaneously hypertensive rats (Lekgabe et al., 2005). In cardiac fibroblasts, relaxin reduces collagen type I and III expression and increases MMPs (Samuel et al., 2004a). In cardiac fibrosis after chronic stimulation of b-adrenoceptors by isoprenaline (Zhang et al., 2005) or by cardiac-specific transgenic overexpression of b2-adrenoceptors (Bathgate e

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