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N renal plasma flow and glomerular filtration rate (Smith et al., 2006a), or the effect may take longer to develop via alteration of the filtration coefficient. For example, during chronic relaxin infusion in the scleroderma trials, the estimated glomerular filtration rate rose significantly in the treated group (Seibold et al., 2000; Khanna et al., 2009). However, the vasodilator effects of relax

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