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Actor (VEGF) in endothelial cells.181 Interestingly, IL-1 seemed to have a more dramatic effect in hypoxic conditions, which fits to the proposed role of IL-1 in the often hypoxic tumor microenvironment. Following these first steps of tumor development, IL-1 takes over and is thus believed to be of greater importance.182 Yet, clinical trials are underway using MABp1 antibody to target IL-1 in the

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