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Streammitogen-activated protein kinase (MAPK) signaling and NFB activation (Figure 2).149,150 Thus, IL-1 activates neighboring fibroblasts or epithelial cells, further triggering the release of chemokines that leads immune cells, preferentially neutrophils,151 to infiltrate and enhance local inflammation. IL-1 in sterile inflammation: from acute to chronic disease As previously mentioned, pIL-1 is

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