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Arly Golgi-specific glycosylation defects and significant perturbation of early but not late Golgi structure (Gaynor and Emr, 1997). In mammalian cells, disruption of COPI function also leads to significant morphological changes in Golgi structure. For example, disruption the function of temperature-sensitive -COP at the nonpermissive temperature in the CHO cell line causes complete disassociation

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