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Ar ImmunologyDual-function alarmins in the heart of inflammation and disease D Bertheloot and E Latzstage tumor growth or blood vessel clogging. Interestingly, pIL-1 expression was shown to be increased before epithelial cell necrosis in a hypoxia-induced factor (HIF)-1a- and HIF-2a-dependent manner.154 The release of IL-1 promotes chemokine secretion and neutrophil infiltration. Moreover, extrace

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