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Ivities (Figure 1A). E3 ligases facilitate the ubiquitylation of substrate proteins to alter their function in various ways, most commonly by triggering substrate degradation (for a detailed description on the impact of ubiquitylation of substrates see the TAB chapter written by Judy Callis on `The Ubiquitination Machinery of the Ubiquitin System'). E3 ligases can either be monomeric, or consist o

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