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T human IFN- is used as a treatment for MS. A study investigating whether IRF8 alleles were associated with type I IFN levels or serologic profiles in SLE and MS revealed that MS-associated allele downstream of IRF8 (rs17445836G) was associated with decreased activity of the type I IFN pathway in these two different autoimmune diseases and was associated with anti-dsDNA antibodies and increased IR

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