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Ect interaction with MyD88, but it does appear to play a role in the TLR pathway as dendritic cells lacking IRF8 do not produce inflammatory cytokines in response to TLR9 ligand [48]. IRF8 deficiency in humans results in an immunodeficiency characterized by the loss of monocytes and dendritic cells, indicating its role in monocyte and dendritic cell development [49]. Genetic variants in the IRF8 g

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