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Also associated with a more severe SLE phenotype characterized by a higher frequency of nephritis and the presence of anti-dsDNA antibodies [54]. 3.3. IFIH1 IFIH1 is an innate immune receptor located in the cytosol which senses dsRNA and promotes IRF3 and 7 phosphorylation, activating transcription of antiviral genes and type I IFN production. Based on the studies in SLE and other various autoimmu

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