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Search results for gs-4997 inhibitor

Progression) we focus on the apical/basal transport of Hh in developing photoreceptors in healthy and disease models, as this is particularly difficult to observe and quantify in other established models of Hh in development (Jiang and Hui, 2008; Yazawa et al., 2009). More broadly, this method could be adapted to additional neurodegenerative disease models (e.g. in the Dmel eye) and should enable
Conserved motif that designates the protein for axonal transport and release at the growth cone. Indeed, HhC (which travels with HhN) is necessary for the proper axonal transport of the N-terminal signaling domain (Chu et al., 2006). To determine whether HhC undergoes axonal transport, we observed trafficking via real-time imaging of axons in live Drosophila larvae (Fig. 2 and see Materials and M
Ble organism.RESULTSIn fly larval photoreceptor neurons the developmental signal Hh is guided to two receptive fields; the apical (retina) and basal (growth cone, GC) ends where secretion of the morphogen is an inductive factor in photoreceptor differentiation and establishment of eyebrain neural connections (Fig. 1A-C) (Huang and Kunes, 1996; Roignant and Treisman, 2009). Hh released apically in

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